AT-108 induces powerful, personalized anti-cancer responses by forcing tumor cells to present their antigens to the immune ...

Cancer cells can disarm the immune system not just by hiding from it, but by actively reprogramming nearby immune cells into a suppressed state. This previously unrecognized molecular interaction, ...

细胞重编程可通过调控细胞命运，诱导获得适用于临床治疗的目标细胞类型，开辟了再生医学新的路径。2006年，日本科学家山中伸弥（Shinya Yamanaka）借助病毒载体将Oct4、Sox2、Klf4和c-Myc四个转录因子（OSKM，即“山中因子”）导入成体细胞，将其重编程为诱导多能干细胞（iPS细胞），是生命科学研究里程碑式的突破。

Leuven, 11 March 2025 – Solid tumors often provide a challenging environment for the T cells of our immune system. By reprogramming the metabolism of T cells, scientists at the VIB-KU Leuven Center ...

A new way of reprogramming our immune cells to shrink or kill off cancer cells has been shown to work in the otherwise hard to treat and devastating skin cancer, melanoma. The discovery demonstrates a ...

One promising strategy to remuscularize the injured heart is the direct cardiac reprogramming of heart fibroblast cells into cardiomyocytes. Researchers have identified TBX20 as the key missing ...

近日， 贵州师范大学团队 在国际顶级学术期刊 《C ell》 在线发表研究论文“Reprogramming of microspore fate via BBM-BAR1 for highly efficient in vivo haploid ...

Researchers at Oregon Health & Science University have uncovered a key reason why immunotherapy has largely failed in pancreatic cancer—and identified a promising strategy to overcome that resistance.

Researchers showed that an experimental therapy indirectly converted suppressive immune cells into tumor-fighting cells. This ...

The capacity of an organism to regenerate depends on cell dedifferentiation followed by proliferation. Mammals, in general, have limited regenerative capacity. Now, a team of researchers at the Salk ...